THERANOSTIC SUPERPARAMAGNETIC IRON OXIDE NANOVECTORS

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21340%2F18%3A00323786" target="_blank" >RIV/68407700:21340/18:00323786 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
THERANOSTIC SUPERPARAMAGNETIC IRON OXIDE NANOVECTORS
Original language description
Superparamagnetic iron oxide nanoparticles (SPIONs) are being widely studied as contrast agents and radionuclide carriers in nuclear medicine and radiology, advantaging of simple preparation, low toxicity, biocompatibility and superparamagnetic properties. Further, SPIONs can be vectorised by an external magnetic field to a target tissue. The scope of our work was the synthesis and characterization of SPIONs and their labelling with: PET radionuclide 18F, 99mTc useful for SPECT diagnostics and with 223Ra for alpha-particle therapy. The magnetite nanoparticles were labelled with 18F (109,7 min), 99mTc (T1/2 = 6 h) and 223Ra (T1/2 = 11,43 d) with excellent yields and their stability was studied for a period of five half-lives in physiological saline, plasma, serum and albumin solution.
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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