An overview of multiphase cartilage mechanical modelling and its role in understanding function and pathology

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21340%2F16%3A00305483" target="_blank" >RIV/68407700:21340/16:00305483 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.jmbbm.2016.04.032" target="_blank" >http://dx.doi.org/10.1016/j.jmbbm.2016.04.032</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jmbbm.2016.04.032" target="_blank" >10.1016/j.jmbbm.2016.04.032</a>

Result language

angličtina

Original language name

An overview of multiphase cartilage mechanical modelling and its role in understanding function and pathology

Original language description

There is a long history of mathematical and computational modelling with the objective of understanding the mechanisms governing cartilage's remarkable mechanical performance. Nonetheless, despite sophisticated modelling development, simulations of cartilage have consistently lagged behind structural knowledge and thus the relationship between structure and function in cartilage is not fully understood. However, in the most recent generation of studies, there is an emerging confluence between our structural knowledge and the structure represented in cartilage modelling. This raises the prospect of further refinement in our understanding of cartilage function and also the initiation of an engineering-level understanding for how structural degradation and ageing relates to cartilage dysfunction and pathology, as well as informing the potential design of prospective interventions. Aimed at researchers entering the field of cartilage modelling, we thus review the basic principles of cartilage models, discussing the underlying physics and assumptions in relatively simple settings, whilst presenting the derivation of relatively parsimonious multiphase cartilage models consistent with our discussions. We proceed to consider modern developments that start aligning the structure captured in the models with observed complexities. This emphasises the challenges associated with constitutive relations, boundary conditions, parameter estimation and validation in cartilage modelling programmes. Consequently, we further detail how both experimental interrogations and modelling developments can be utilised to investigate and reduce such difficulties before summarising how cartilage modelling initiatives may improve our understanding of cartilage ageing, pathology and intervention. (C) 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BO - Biophysics

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of the Mechanical Behavior of Biomedical Materials

ISSN

1751-6161

e-ISSN

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Volume of the periodical

62

Issue of the periodical within the volume

September

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

19

Pages from-to

139-157

UT code for WoS article

000381238500013

EID of the result in the Scopus database

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