Regular chondrocyte spacing is a potential cause for coherent ultrasound backscatter in human articular cartilage
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21340%2F17%3A00312171" target="_blank" >RIV/68407700:21340/17:00312171 - isvavai.cz</a>
Result on the web
<a href="http://asa.scitation.org/doi/abs/10.1121/1.4979339" target="_blank" >http://asa.scitation.org/doi/abs/10.1121/1.4979339</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1121/1.4979339" target="_blank" >10.1121/1.4979339</a>
Alternative languages
Result language
angličtina
Original language name
Regular chondrocyte spacing is a potential cause for coherent ultrasound backscatter in human articular cartilage
Original language description
The potential of quantitative ultrasound (QUS) to assess the regular cellular spacing in the superficial cartilage zones was investigated experimentally and numerically. Nine osteochondral samples, extracted from two human cadaver knee joints, were measured using a 50-MHz ultrasound scanning device and evaluated using Mankin score. Simulated backscattered power spectra from models with an idealized cell alignment exhibited a pronounced frequency peak. From the peak, cell spacing in the range between 15 and 40 μm between cell layers was detected with an average error of 0.2 μm. The mean QUS-based cell spacing was 28.3 ± 5.3 μm. Strong correlation (R2 = 0.59, p <= 0.001) between spacing estimates from light microscopy (LM) and QUS was found for samples with Mankin score <=3. For higher scores, QUS-based spacing was significantly higher (p <= 0.05) compared to LM-based spacing. QUS-based spacing estimates together with other QUS parameters may serve as future biomarkers for detecting early signs of osteoarthrosis.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10307 - Acoustics
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
The Journal of the Acoustical Society of America
ISSN
0001-4966
e-ISSN
1520-8524
Volume of the periodical
141
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
3105-3116
UT code for WoS article
000403270600026
EID of the result in the Scopus database
2-s2.0-85019043455