Study of Radioactive Progeny Recoils Release from 225Ac Labelled TiO2 Nanoparticles
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21340%2F22%3A00365031" target="_blank" >RIV/68407700:21340/22:00365031 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/article/10.1007/s00259-022-05924-4" target="_blank" >https://link.springer.com/article/10.1007/s00259-022-05924-4</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Study of Radioactive Progeny Recoils Release from 225Ac Labelled TiO2 Nanoparticles
Original language description
Targeted alpha therapy (TAT) plays important role in palliative as well as curative treatment of patients with oncological diseases. Several radionuclides suitable for TAT are decay by emission of α-particle cascade, which can on one hand improve therapeutic outcome, but on the other hand also cause severe damage to non-target tissues. One strategy to least partially reduce this progeny spread over the body is based on the use of nanoparticles (NPs) [2]. The aim of this work was to determine the fraction of recoiling atoms activity originating from 225Ac decay (221Fr, 213Bi) and study the progeny wash-out dependence over time and on the concentration of TiO2 NPs as a potential carrier of radionuclides for TAT.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
10402 - Inorganic and nuclear chemistry
Result continuities
Project
<a href="/en/project/TJ04000129" target="_blank" >TJ04000129: Separation of radionuclides for targeted alpha particle therapy</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů