Inhouse production of 161Tb
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21340%2F24%3A00378185" target="_blank" >RIV/68407700:21340/24:00378185 - isvavai.cz</a>
Result on the web
<a href="https://events.ncbj.gov.pl/event/322/attachments/601/976/Book_of_abstracts.pdf" target="_blank" >https://events.ncbj.gov.pl/event/322/attachments/601/976/Book_of_abstracts.pdf</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Inhouse production of 161Tb
Original language description
Terbium-161 is a promising theragnostic nuclide that offers low energy and Auger-Meitner electron emissions with low energy gamma rays for SPECT imaging. It could fill the gap between the powerful and more toxic 225Ac, and currently used beta emitter, the 177Lu. Due to scarsity of the enriched 160Gd tagert material its availability is limited. We report here the inhouse production of 161Tb using the 160Gd(n,γ)161Gd -> 161Tb reactions sequence leading to a product suitable for preclinical and potentially clinical trials. Production and possible further developments will be discussed in the presentation, including enriched 160Gd target preparation, its irradiation in a nuclear reactor, Gd/Tb separation, Tb product purification and formulation, enriched Gd recycling and labelling tests with the prepared 161Tb. Up today, some 20 production runs were performed in our laboratory resulting in an overal 161Tb activity sum of AEOB = 150 GBq. Final product activities ranged up to AEOB = 22 GBq per batch, resulting in high-purity 161Tb of radionuclidic purity over 99,999 % and a mass specific activity in the range of am(Tb) = 1,9 – 4 GBq/μg. An outlook to possible regular 161Tb production in the Czech Republic is given with a discussion on future 161Tb developments.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
10402 - Inorganic and nuclear chemistry
Result continuities
Project
<a href="/en/project/TO01000074" target="_blank" >TO01000074: Efficient Low-energy Electron Cancer Therapy with Terbium-161</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů