Effects of Echinochrome on Ventricular Repolarization in Acute Ischemia

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F14%3A00218888" target="_blank" >RIV/68407700:21460/14:00218888 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Effects of Echinochrome on Ventricular Repolarization in Acute Ischemia
Original language description
Ischemia-related processes, including electrophysiological alterations, are associated with the generation of reactive oxygen species. Although the cardioprotective action of antioxidants against ischemic injury has been proposed, their electrophysiological effects are not clear. The aim of this study was to investigate the effects of the antioxidant Echinochrome on ischemia-induced alterations of ventricular repolarization in a feline model of coronary occlusion. Experiments were performed on open-chest anesthetized adult cats. Activation-recovery intervals were measured from 64 ventricular epicardial unipolar electrograms recorded simultaneously before and during ligation of the left anterior descending coronary artery. Synthetic Echinochrome was infused five minutes before coronary occlusion in two different doses (1.0 mg/kg and 2.0 mg/kg, i.v.). Pre-occlusion administration of Echinochrome in a dose of 1.0 mg/kg resulted in the reduction of ischemiainduced shortening of activation-
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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