Effects of Echinochrome on Ventricular Repolarization in Acute Ischemia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F15%3A00239026" target="_blank" >RIV/68407700:21460/15:00239026 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.jelectrocard.2015.01.003" target="_blank" >http://dx.doi.org/10.1016/j.jelectrocard.2015.01.003</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jelectrocard.2015.01.003" target="_blank" >10.1016/j.jelectrocard.2015.01.003</a>
Alternative languages
Result language
angličtina
Original language name
Effects of Echinochrome on Ventricular Repolarization in Acute Ischemia
Original language description
Background: Myocardial ischemic electrophysiological alterations are associated with the generation of reactive oxygen species. However, electrophysiological effects of antioxidants are unclear. Our objective was to determine the effects of the antioxidant echinochrome on ventricular repolarization in a feline model of 30-min ischemia. Methods and results: Activation recovery intervals were measured from 64 ventricular electrograms recorded before and during the LAD ligation in untreated animals (controls, n = 5) and animals given echinochrome (1 mg/kg, n = 5 and 2 mg/kg, n = 7). In controls, ischemia resulted in the increase of repolarization dispersion, QTc and Tpeak Tend intervals and precordial T wave amplitude dispersion. Echinochrome attenuated the ischemic increase of repolarization dispersion. The increased dose of echinochrome abolished the ischemic ECG repolarization changes but did not modify the incidence of ventricular arrhythmias. Conclusion: Echinochrome modified ischemi
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Electrocardiology
ISSN
0022-0736
e-ISSN
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Volume of the periodical
48
Issue of the periodical within the volume
2
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
6
Pages from-to
181-186
UT code for WoS article
000353075600009
EID of the result in the Scopus database
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