Managing of ventricular reperfusion tachyarrhythmias - focus on a perfused myocardium

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F19%3A00338966" target="_blank" >RIV/68407700:21460/19:00338966 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.26402/jpp.2019.5.11" target="_blank" >https://doi.org/10.26402/jpp.2019.5.11</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.26402/jpp.2019.5.11" target="_blank" >10.26402/jpp.2019.5.11</a>

Result language

angličtina

Original language name

Managing of ventricular reperfusion tachyarrhythmias - focus on a perfused myocardium

Original language description

In this study we tested a hypothesis that reperfusion ventricular tachyarrhythmias can be modified by direct control of repolarization duration in the perfused myocardium during ischemic exposure. After induction of coronary occlusion, three groups of rats were given agencies affecting repolarization duration tetraethylammonium (TEA) 4 mg/kg, n = 9; pinacidil (Pin) 0.3 mg/kg, n = 11, and saline as placebo (control) n = 10. Unipolar electrograms were recorded from ischemic and perfused areas using an array of 64-electrodes to obtain activation times (ATs), repolarization times (RTs), activation-repolarization intervals (ARIs) and dispersion of repolarization (DOR). During ischemia/reperfusion ARIs in perfused area did not change in the control, significantly increased in the TEA and decreased in the Pin group in respect to baseline, whereas ARIs significantly decreased in the ischemic zone in all groups. DOR also significantly increased in all groups at ischemia and reperfusion. The incidence and total arrhythmia score of reperfusion tachyarrhythmias were significantly greater in TEA group compared to Pin and control groups. In multivariate regression analysis, incidence of VT/VFs and total arrhythmia score were associated with ARIs in the perfused area. Thus, the effect on repolarization durations in the perfused area modified the incidence and severity of the reperfusion-induced ventricular tachyarrhythmias.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30109 - Pathology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of physiology and pharmacology

ISSN

0867-5910

e-ISSN

—

Volume of the periodical

70

Issue of the periodical within the volume

5

Country of publishing house

PL - POLAND

Number of pages

7

Pages from-to

757-763

UT code for WoS article

000519846400003

EID of the result in the Scopus database

2-s2.0-85078833058