Polycaprolactone Foam Functionalized With Chitosan Microparticles – a Suitable Scaffold for Cartilage Regeneration

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F16%3A00310860" target="_blank" >RIV/68407700:21460/16:00310860 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/16:00459654 RIV/68378041:_____/16:00459654 RIV/46747885:24410/16:00000418 RIV/62157124:16170/16:43874320
Result on the web
<a href="http://www.biomed.cas.cz/physiolres/pdf/65/65_121.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/65/65_121.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Polycaprolactone Foam Functionalized With Chitosan Microparticles – a Suitable Scaffold for Cartilage Regeneration
Original language description
For biodegradable porous scaffolds to have a potential application in cartilage regeneration, they should enable cell growth and differentiation and should have adequate mechanical properties. In this study, our aim was to prepare biocompatible scaffolds with improved biomechanical properties. To this end, we have developed foam scaffolds from poly-epsilon-caprolactone (PCL) with incorporated chitosan microparticles. The scaffolds were prepared by a salt leaching technique from either 10 or 15 wt% PCL solutions containing 0, 10 and 20 wt% chitosan microparticles, where the same amount and size of NaCl was used as a porogen in all the cases. PCL scaffolds without and with low amounts of chitosan (0 and 10 wt% chitosan) showed higher DNA content than scaffolds with high amounts of chitosan during a 22-day experiment. 10 wt% PCL with 10 and 20 wt% chitosan showed significantly increased viscoelastic properties compared to 15 wt% PCL scaffolds with 0 and 10 wt% chitosan. Thus, 10 wt% PCL scaffolds with 0 wt% and 10 wt% chitosan are potential scaffolds for cartilage regeneration.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FI - Traumatology and orthopaedics
OECD FORD branch
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Project
<a href="/en/project/NT12156" target="_blank" >NT12156: Novel scaffolds for osteochondral regeneration based on core/shell nanofibers enriched with a drug delivery system</a><br>
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year
2016
Confidentiality
C - Předmět řešení projektu podléhá obchodnímu tajemství (§ 504 Občanského zákoníku), ale název projektu, cíle projektu a u ukončeného nebo zastaveného projektu zhodnocení výsledku řešení projektu (údaje P03, P04, P15, P19, P29, PN8) dodané do CEP, jsou upraveny tak, aby byly zveřejnitelné.

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