Estimation of influence of Leishmania major infection on mouse gut microbiomeby tools of molecular genetics

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F18%3A00325938" target="_blank" >RIV/68407700:21460/18:00325938 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Estimation of influence of Leishmania major infection on mouse gut microbiomeby tools of molecular genetics
Original language description
Leishmaniasis is a disease caused by the protozoan parasite genus Leishmania. The disease is a current health problem in 98 countries worldwide. There is increasing knowledge about Leishmaniasis manifestation and its immunological background, but limited information about the microbiota dysbiosis caused by the disease. Gastrointestinal tract microbiota plays role in the development of immune system. The study was aimed to better understand the complex pathogenesis of Leishmania infection by examination of influence of Leishmania major on gut microbiome of mammalian host. The microbiome diversities were estimated by PCR-DGGE method, selected bands were identified by Sanger sequencing which led to dendrogram creation and cluster analysis. In the study a weight loss and lesions appeared in susceptible mice. There were bands identfied as Lactobacillus taiwanensis in colon samples. No significant linkage between strains was observed.
Czech name
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Czech description
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Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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