Predictive value of SAR based quality indicators for head and neck hyperthermia treatment quality
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F19%3A00331394" target="_blank" >RIV/68407700:21460/19:00331394 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1080/02656736.2019.1590652" target="_blank" >https://doi.org/10.1080/02656736.2019.1590652</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/02656736.2019.1590652" target="_blank" >10.1080/02656736.2019.1590652</a>
Alternative languages
Result language
angličtina
Original language name
Predictive value of SAR based quality indicators for head and neck hyperthermia treatment quality
Original language description
Purpose: Hyperthermia treatment quality determines treatment effectiveness as shown by the clinically derived thermal-dose effect relations. SAR based optimization factors are used as possible surrogate for temperature, since they are not affected by thermal tissue properties uncertainty and variations. Previously, target coverage (TC) at the 25% and 50% iso-SAR level was shown predictive for treatment outcome in superficial hyperthermia and the target-to-hot-spot-quotient (THQ) was shown to highly correlate with predictive temperature in deep pelvic hyperthermia. Here, we investigate the correlation with temperature for THQ and TC using an 'intermediate' scenario: semi-deep hyperthermia in the head & neck region using the HYPERcollar3D. Methods: Fifteen patient-specific models and two different planning approaches were used, including random perturbations to circumvent optimization bias. The predicted SAR indicators were compared to predicted target temperature distribution indicators T50 and T90, i.e., the median and 90th percentile temperature respectively. Results: The intra-patient analysis identified THQ, TC25 and TC50 as good temperature surrogates: with a mean correlation coefficient R-T50(2) = 0.72 and R-T90(2)=0.66. The inter-patient analysis identified the highest correlation with TC25 (R-T50(2) = 0.76, R-T90(2)=0.54) and TC50 (R-T50(2) = 0.74, R-T90(2) = 0.56). Conclusion: Our investigation confirmed the validity of our current strategy for deep hyperthermia in the head & neck based on a combination of THQ and TC25. TC50 was identified as the best surrogate since it enables optimization and patient inclusion decision making using one single parameter.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20201 - Electrical and electronic engineering
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
INTERNATIONAL JOURNAL OF HYPERTHERMIA
ISSN
0265-6736
e-ISSN
1464-5157
Volume of the periodical
36
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
456-465
UT code for WoS article
000466676500001
EID of the result in the Scopus database
2-s2.0-85064490494