Preventive Administration of Melatonin Attenuates Electrophysiological Consequences of Myocardial Ischemia

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F20%3A00342559" target="_blank" >RIV/68407700:21460/20:00342559 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1007/s10517-020-04881-y" target="_blank" >https://doi.org/10.1007/s10517-020-04881-y</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10517-020-04881-y" target="_blank" >10.1007/s10517-020-04881-y</a>

Result language
angličtina
Original language name
Preventive Administration of Melatonin Attenuates Electrophysiological Consequences of Myocardial Ischemia
Original language description
The effect of preventive administration of melatonin on the arrhythmogenic substrate in the myocardium was studied in the rabbit model of acute ischemia/reperfusion in vivo. The animals treated with melatonin 60 min before ischemia induction had shorter median activation time compared to the control group (p=0.039), less pronounced shortening of repolarization durations in the ischemic zone during coronary occlusion (p=0.008), and more complete recovery of repolarization during reperfusion (p=0.027). In the melatonin group, the dispersion of repolarization was less than in the control group during both ischemic period (p=0.043) and reperfusion (p=0.038). Thus, preventive administration of melatonin mitigated the arrhythmogenic substrate in the heart under conditions of ischemia/reperfusion.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30109 - Pathology

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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