Comparison of multipotent mesenchymal stromal cells from human adipose tissue and Wharton's jelly for soft tissue reconstruction

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F20%3A00348844" target="_blank" >RIV/68407700:21460/20:00348844 - isvavai.cz</a>
Alternative codes found
RIV/68407700:21720/20:00348844
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Comparison of multipotent mesenchymal stromal cells from human adipose tissue and Wharton's jelly for soft tissue reconstruction
Original language description
Adipose tissue engineering, based on the application of multipotent mesenchymal stromal cells (MSCs) represents a promising strategy to restore soft tissue defects. The source of MSCs for the application in adipose tissue engineering may determine the efficiency of reconstruction strategy. The capacity to differentiate towards adipogenic lineage is one of the criteria defining fibroblast-like cells to MSC. However, the efficiency of the differentiation depending on the source of cell isolation is not determined as a standard and comparative studies are needed to find the optimal source of MSC for adipose / soft tissue reconstruction. The aim of the study was to evaluate the potential of MSCs derived from adipose tissue (AT) and Wharton’s jelly (WJ) for adipose tissue engineering. We assessed the effect of the presence of serum in the adipogenic differentiation medium. Finally, we assessed the possibility of using established culture and differentiation conditions for the adipose tissue engineering in 3D collagen scaffolds.
Czech name
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Czech description
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Type
O - Miscellaneous
CEP classification
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OECD FORD branch
30402 - Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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