Emulsion Centrifugal Spinning for Production of 3D Drug Releasing Nanofibers with Core/Shell Structure

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21720%2F17%3A00310206" target="_blank" >RIV/68407700:21720/17:00310206 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1039/c6ra26606a" target="_blank" >http://dx.doi.org/10.1039/c6ra26606a</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c6ra26606a" target="_blank" >10.1039/c6ra26606a</a>

Result language

angličtina

Original language name

Emulsion Centrifugal Spinning for Production of 3D Drug Releasing Nanofibers with Core/Shell Structure

Original language description

Herein we describe the core/shell centrifugal spinning process to deliver susceptible bioactive molecules. The fibres are produced from water-in-oil (W/O) emulsion, where poly-ε-caprolactone (PCL) dissolved in chloroform serves as the continuous phase and Pluronic F-68 (PF-68) dissolved in ethanol serves as the droplet phase. The successful core/shell fibre formation and discontinuous morphology of the core was identified by confocal microscopy. Encapsulation of a model enzyme resulted in protection of enzymatic activity and release during the first 7 days. The feasibility for tissue engineering applications was demonstrated by the incorporation of platelet lyophilisates as a source of growth factors. The cultivation of 3T3 fibroblasts and MG63 osteoblasts resulted in improved metabolic activity and fostered proliferation. Results of the study indicate that the proposed scaffold combines the 3D structure of scaffolds produced by centrifugal spinning with the drug delivery of growth factors.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

21001 - Nano-materials (production and properties)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

RSC Advances

ISSN

2046-2069

e-ISSN

2046-2069

Volume of the periodical

7

Issue of the periodical within the volume

3

Country of publishing house

GB - UNITED KINGDOM

Number of pages

14

Pages from-to

1215-1228

UT code for WoS article

000393744400003

EID of the result in the Scopus database

2-s2.0-85009391363