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A polypropylene mesh modified with polye-epsilon-caprolactone nanofibers in hernia repair: large animal experiment

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21720%2F18%3A00324290" target="_blank" >RIV/68407700:21720/18:00324290 - isvavai.cz</a>

  • Alternative codes found

    RIV/68378041:_____/18:00492334 RIV/68407700:21460/18:00324290 RIV/00216208:11130/18:10375744 RIV/00216208:11140/18:10375744 and 3 more

  • Result on the web

    <a href="https://www.dovepress.com/a-polypropylene-mesh-modified-with-poly-epsilon-caprolactone-nanofiber-peer-reviewed-article-IJN" target="_blank" >https://www.dovepress.com/a-polypropylene-mesh-modified-with-poly-epsilon-caprolactone-nanofiber-peer-reviewed-article-IJN</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.2147/IJN.S159480" target="_blank" >10.2147/IJN.S159480</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    A polypropylene mesh modified with polye-epsilon-caprolactone nanofibers in hernia repair: large animal experiment

  • Original language description

    Purpose: Incisional hernia repair is an unsuccessful field of surgery, with long-term recurrence rates reaching up to 50% regardless of technique or mesh material used. Various implants and their positioning within the abdominal wall pose numerous long-term complications that are difficult to treat due to their permanent nature and the chronic foreign body reaction they trigger. Materials mimicking the 3D structure of the extracellular matrix promote cell adhesion, proliferation, migration, and differentiation. Some electrospun nanofibrous scaffolds provide a topography of a natural extracellular matrix and are cost effective to manufacture. Materials and methods: A composite scaffold that was assembled out of a standard polypropylene hernia mesh and poly-epsilon-caprolactone (PCL) nanofibers was tested in a large animal model (minipig), and the final scar tissue was subjected to histological and biomechanical testing to verify our in vitro results published previously. Results: We have demonstrated that a layer of PCL nanofibers leads to tissue overgrowth and the formation of a thick fibrous plate around the implant. Collagen maturation is accelerated, and the final scar is more flexible and elastic than under a standard polypropylene mesh with less pronounced shrinkage observed. However, the samples with the composite scaffold were less resistant to distracting forces than when a standard mesh was used. We believe that the adverse effects could be caused due to the material assembly, as they do not comply with our previous results. Conclusion: We believe that PCL nanofibers on their own can cause enough fibroplasia to be used as a separate material without the polypropylene base, thus avoiding potential adverse effects caused by any added substances.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30500 - Other medical sciences

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    International Journal of Nanomedicine

  • ISSN

    1178-2013

  • e-ISSN

    1178-2013

  • Volume of the periodical

    13

  • Issue of the periodical within the volume

    May

  • Country of publishing house

    NZ - NEW ZEALAND

  • Number of pages

    15

  • Pages from-to

    3129-3143

  • UT code for WoS article

    000433196800001

  • EID of the result in the Scopus database

    2-s2.0-85047892517