Electrical Stimulation Modulates High Gamma Activity and Human Memory Performance.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21730%2F18%3A00319218" target="_blank" >RIV/68407700:21730/18:00319218 - isvavai.cz</a>

Result on the web

<a href="http://www.eneuro.org/content/early/2018/01/24/ENEURO.0369-17.2018" target="_blank" >http://www.eneuro.org/content/early/2018/01/24/ENEURO.0369-17.2018</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1523/ENEURO.0369-17.2018" target="_blank" >10.1523/ENEURO.0369-17.2018</a>

Result language

angličtina

Original language name

Electrical Stimulation Modulates High Gamma Activity and Human Memory Performance.

Original language description

Direct electrical stimulation of the brain has emerged as a powerful treatment for multiple neurological diseases, and as a potential technique to enhance human cognition. Despite its application in a range of brain disorders, it remains unclear how stimulation of discrete brain areas affects memory performance and the underlying electrophysiological activities. Here, we investigated the effect of direct electrical stimulation in four brain regions known to support declarative memory: hippocampus, parahippocampal neocortex, prefrontal cortex and lateral temporal cortex. Intracranial EEG recordings with stimulation were collected from 22 patients during performance of verbal memory tasks. We found that high gamma (62-118 Hz) activity induced by word presentation was modulated by electrical stimulation. This modulatory effect was greatest for trials with `poor’ memory encoding. The high gamma modulation correlated with the behavioral effect of stimulation in a given brain region – it was negative, i.e. the induced high gamma activity was decreased, in the regions where stimulation decreased memory performance, and positive in the lateral temporal cortex where memory enhancement was observed. Our results suggest that the effect of electrical stimulation on high gamma activity induced by word presentation may be a useful biomarker for mapping memory networks and guiding therapeutic brain stimulation.

Czech name

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Czech description

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Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

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OECD FORD branch

20601 - Medical engineering

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

eNeuro

ISSN

2373-2822

e-ISSN

2373-2822

Volume of the periodical

5

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

14

Pages from-to

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UT code for WoS article

000429409900047

EID of the result in the Scopus database

2-s2.0-85042085339