Regional associations between cerebrovascular disease and cholinergic white matter pathways in the Lewy body continuum
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21730%2F25%3A00385966" target="_blank" >RIV/68407700:21730/25:00385966 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1038/s41531-025-01118-5" target="_blank" >https://doi.org/10.1038/s41531-025-01118-5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41531-025-01118-5" target="_blank" >10.1038/s41531-025-01118-5</a>
Alternative languages
Result language
angličtina
Original language name
Regional associations between cerebrovascular disease and cholinergic white matter pathways in the Lewy body continuum
Original language description
Cerebrovascular disease is common in patients on the Lewy body (LB) continuum (dementia with Lewy bodies (DLB) and prodromal-DLB). White matter signal abnormality (WMSA) volume is higher in patients with LB than controls, both globally and in cholinergic white matter. However, it remains unknown if the higher WMSA in cholinergic white matter reflects selective cholinergic vulnerability or results from higher global WMSA. We modelled cingulate and external capsule cholinergic white matter pathways using MRI and segmented WMSA overlapping cholinergic pathways and per brain lobe. We found that patients on the LB-continuum (n = 33) had higher volume and proportion of WMSA in the cholinergic white matter compared to controls (n = 36), independent of global WMSA. Cholinergic WMSA was associated with neurodegeneration in the basal forebrain, decreased integrity of cingulate and external capsule pathways and attention and memory performance. These findings may suggest a selective vulnerability of cholinergic pathways in patients with LB.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20601 - Medical engineering
Result continuities
Project
<a href="/en/project/GM25-18359M" target="_blank" >GM25-18359M: Quantitative Structural and Functional Imaging of the Human Cholinergic System with Applications in Cognitive Science and Neurodegenerative Disorders</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
npj Parkinsons Disease
ISSN
2373-8057
e-ISSN
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Volume of the periodical
11
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
1-10
UT code for WoS article
001554531500001
EID of the result in the Scopus database
2-s2.0-105013865143