Cerebrovascular disease, neurodegeneration, and clinical phenotype in dementia with Lewy bodies

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F21%3A00075051" target="_blank" >RIV/00159816:_____/21:00075051 - isvavai.cz</a>

Alternative codes found

RIV/00064203:_____/21:10428504 RIV/00216208:11130/21:10428504

Result on the web

<a href="https://www.sciencedirect.com/science/article/abs/pii/S0197458021001536?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0197458021001536?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.neurobiolaging.2021.04.029" target="_blank" >10.1016/j.neurobiolaging.2021.04.029</a>

Result language

angličtina

Original language name

Cerebrovascular disease, neurodegeneration, and clinical phenotype in dementia with Lewy bodies

Original language description

We investigated whether cerebrovascular disease contributes to neurodegeneration and clinical phenotype in dementia with Lewy bodies (DLB). Regional cortical thickness and subcortical gray matter volumes were estimated from structural magnetic resonance imaging (MRI) in 165 DLB patients. Cortical and subcortical infarcts were recorded and white matter hyperintensities (WMHs) were assessed. Subcortical only infarcts were more frequent (13.3%) than cortical only infarcts (3.1%) or both subcortical and cortical infarcts (2.4%). Infarcts, irrespective of type, were associated with WMHs. A higher WMH volume was associated with thinner orbitofrontal, retrosplenial, and posterior cingulate cortices, smaller thalamus and pallidum, and larger caudate volume. A higher WMH volume was associated with the presence of visual hallucinations and lower global cognitive performance, and tended to be associated with the absence of probable rapid eye movement sleep behavior disorder. Presence of infarcts was associated with the absence of parkinsonism. We conclude that cerebrovascular disease is associated with gray matter neurodegeneration in patients with probable DLB, which may have implications for the multifactorial treatment of probable DLB. (c) 2021 Elsevier Inc. All rights reserved.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30227 - Geriatrics and gerontology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neurobiology of Aging

ISSN

0197-4580

e-ISSN

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Volume of the periodical

105

Issue of the periodical within the volume

September

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

252-261

UT code for WoS article

000680064700023

EID of the result in the Scopus database

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