Sex differences in brain atrophy in dementia with Lewy bodies
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F23%3A00133508" target="_blank" >RIV/00216224:14740/23:00133508 - isvavai.cz</a>
Result on the web
<a href="https://alz-journals.onlinelibrary.wiley.com/doi/epdf/10.1002/alz.13571" target="_blank" >https://alz-journals.onlinelibrary.wiley.com/doi/epdf/10.1002/alz.13571</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/alz.13571" target="_blank" >10.1002/alz.13571</a>
Alternative languages
Result language
angličtina
Original language name
Sex differences in brain atrophy in dementia with Lewy bodies
Original language description
INTRODUCTIONSex influences neurodegeneration, but it has been poorly investigated in dementia with Lewy bodies (DLB). We investigated sex differences in brain atrophy in DLB using magnetic resonance imaging (MRI).METHODSWe included 436 patients from the European-DLB consortium and the Mayo Clinic. Sex differences and sex-by-age interactions were assessed through visual atrophy rating scales (n = 327; 73 +/- 8 years, 62% males) and automated estimations of regional gray matter volume and cortical thickness (n = 165; 69 +/- 9 years, 72% males).RESULTSWe found a higher likelihood of frontal atrophy and smaller volumes in six cortical regions in males and thinner olfactory cortices in females. There were significant sex-by-age interactions in volume (six regions) and cortical thickness (seven regions) across the entire cortex.DISCUSSIONWe demonstrate that males have more widespread cortical atrophy at younger ages, but differences tend to disappear with increasing age, with males and females converging around the age of 75.HighlightsMale DLB patients had higher odds for frontal atrophy on radiological visual rating scales.Male DLB patients displayed a widespread pattern of cortical gray matter alterations on automated methods.Sex differences in gray matter measures in DLB tended to disappear with increasing age.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30210 - Clinical neurology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ALZHEIMERS & DEMENTIA
ISSN
1552-5260
e-ISSN
1552-5279
Volume of the periodical
20
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
1815-1826
UT code for WoS article
001129490000001
EID of the result in the Scopus database
2-s2.0-85180259158