Gray Matter Atrophy In Presymptomatic Huntington's Patients
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F16%3A00065975" target="_blank" >RIV/00159816:_____/16:00065975 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.18071/isz.69.0261" target="_blank" >http://dx.doi.org/10.18071/isz.69.0261</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.18071/isz.69.0261" target="_blank" >10.18071/isz.69.0261</a>
Alternative languages
Result language
angličtina
Original language name
Gray Matter Atrophy In Presymptomatic Huntington's Patients
Original language description
Background Huntington's disease is a progressive disease in which neurodegeneration is on-going from the early presymptomatic phase. Development of sensitive biomarkers in this presymptomatic stage that are able to monitor the disease progression and test the efficacy of putative neuroprotective treatments are essential. Methods Seven presymptomatic Huntington mutation carriers and ten age-matched healthy controls were recruited. Six of the patients participated in a 24 months longitudinal study having MRI scans 12 and 24 months after the baseline measurements. High resolution T1 weighted images were carried out and voxel based morphometry was used to analyse the data. Apart of group differences, correlation of CAG repeat number with focal cortical thickness and with global gray matter volume was calculated. Results Focal cortical atrophy was found bilaterally in the superior temporal sulcus and in the left middle frontal gyrus in presymptomatic Huntington patients in whom no sign of cognitive or motor deterioration was detected. Global gray matter atrophy (p<0.048) and decreased total brain volume was found. The number of CAG triplets showed no correlation with the focal gray matter atrophy and total brain volume. Strong correlation between the CAG repeat number and global gray matter volume was found (p<0.016). Conclusion Cortical atrophy is apparent in the early, presymptomatic stage of the disease. With further validation in large patient sample atrophy measure could be biomarker of disease progression and putatively of neurodegeneration.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Ideggyogyaszati Szemle-Clinical Neuroscience
ISSN
0019-1442
e-ISSN
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Volume of the periodical
69
Issue of the periodical within the volume
7-8
Country of publishing house
HU - HUNGARY
Number of pages
7
Pages from-to
261-267
UT code for WoS article
000380866700007
EID of the result in the Scopus database
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