C60 Fullerene Derivative: Influence of Nanoparticle Size on Toxicity and Radioprotectivity of Water Soluble Fullerene Derivative

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70565813%3A_____%2F11%3A%230000251" target="_blank" >RIV/70565813:_____/11:#0000251 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
C60 Fullerene Derivative: Influence of Nanoparticle Size on Toxicity and Radioprotectivity of Water Soluble Fullerene Derivative
Original language description
This work is a follow-up to an earlier one in which we presented the radioprotective properties of a water-soluble C60 fullerene derivative (DF) which had been obtained by a reaction of C60 fullerene with peracetic acid and subsequent hydrolysis. Radioprotective properties were proven in vivo (testing organism-danio rerio, the concentration of DF solution 147 mg/L) as were its non-toxic properties on this sensitive organism. But we observed cytotoxic properties in vitro on guinea pig kidney cells (as atesting culture) and largely on melanoma cells. In this work we pursued the reasons for cell toxicity. We used the NanoSight LM10HSB analysis for determining the nanoparticle size and concentration in used DF solution of 147 mg/L. It was confirmed that the system contained larger particles than 100 nm and was polydispersed. After filtration with a 0.1 ?m filter and under a 20x and 10xobjective, the system showed a nice and quite monodispersed distribution of modal particle size 42 nm+53
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
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Project
<a href="/en/project/VG20102014049" target="_blank" >VG20102014049: Research of the possibilities for application of a new materials (focusing on nano-materials) and advanced technologies for protection of people against the exposure to CBRN materials, with emphasis on critical infrastructure</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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