Effect of model flavonolignan on metabolism of warfarin in rats in vitro
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F11%3A43865998" target="_blank" >RIV/70883521:28110/11:43865998 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Effect of model flavonolignan on metabolism of warfarin in rats in vitro
Original language description
Warfarin, a known anticoagulant, was initially marketed as a rodenticide. Warfarin was found to be effective and relatively safe in prevention of thrombosis and embolism. Several forms of liver microsomal cytochrome P450 (CYP) are known to metabolize warfarin. Hydroxylation of warfarin in rats is mainly catalyzed by enzymes of CYP2C, CYP2B, CYPIA, and CYP3A subfamilies. Five primary metabolites were identified as 4'-hydroxywarfarin, 6-hydroxywarfarin, 7-hydroxywarfarin, 8 -hydroxywarfarin, and 1O-hydroxywarfarin. Inhibitory properties of silybin on 7-hydroxylation of warfarin (CYP2C9) using human liver microsomes and a recombinant CYP2C9 enzyme is known. Warfarin interactions lead to difficulties with titration of a right dose of this drug. A typical flavonolignan, silybin (main component of silymarin), was chosen in this study to evaluate its possible effect on warfarin metabolism in male rats in vitro. The HPLC method for determination of metabolism of warfarin in rats in vitro was i
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Interdisciplinary Toxicology
ISSN
1337-6853
e-ISSN
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Volume of the periodical
4
Issue of the periodical within the volume
2
Country of publishing house
SK - SLOVAKIA
Number of pages
2
Pages from-to
"A63"-"A64"
UT code for WoS article
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EID of the result in the Scopus database
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