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Effect of model flavonolignan on metabolism of warfarin in rats in vitro

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F11%3A43865998" target="_blank" >RIV/70883521:28110/11:43865998 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Effect of model flavonolignan on metabolism of warfarin in rats in vitro

  • Original language description

    Warfarin, a known anticoagulant, was initially marketed as a rodenticide. Warfarin was found to be effective and relatively safe in prevention of thrombosis and embolism. Several forms of liver microsomal cytochrome P450 (CYP) are known to metabolize warfarin. Hydroxylation of warfarin in rats is mainly catalyzed by enzymes of CYP2C, CYP2B, CYPIA, and CYP3A subfamilies. Five primary metabolites were identified as 4'-hydroxywarfarin, 6-hydroxywarfarin, 7-hydroxywarfarin, 8 -hydroxywarfarin, and 1O-hydroxywarfarin. Inhibitory properties of silybin on 7-hydroxylation of warfarin (CYP2C9) using human liver microsomes and a recombinant CYP2C9 enzyme is known. Warfarin interactions lead to difficulties with titration of a right dose of this drug. A typical flavonolignan, silybin (main component of silymarin), was chosen in this study to evaluate its possible effect on warfarin metabolism in male rats in vitro. The HPLC method for determination of metabolism of warfarin in rats in vitro was i

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CE - Biochemistry

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Others

  • Publication year

    2011

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Interdisciplinary Toxicology

  • ISSN

    1337-6853

  • e-ISSN

  • Volume of the periodical

    4

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    SK - SLOVAKIA

  • Number of pages

    2

  • Pages from-to

    "A63"-"A64"

  • UT code for WoS article

  • EID of the result in the Scopus database