Preparation of Labelled 3-(1-adamantyl)-6-methyl-3-(3-methylbenzyl)[18O]isochroman-1-one

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F11%3A43867175" target="_blank" >RIV/70883521:28110/11:43867175 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Preparation of Labelled 3-(1-adamantyl)-6-methyl-3-(3-methylbenzyl)[18O]isochroman-1-one
Original language description
Isochroman-1-one derivate was detected in crude product of the reaction of adamantane-1-carbonyl chloride with 3-methylbenzylmagnesium chloride. although this reaction is known already for five years,[1] the mechanism of formation of isochromanone derivate is not clarified yet. The most important question is how many oxygen atoms in isochroman-1-one originated from adamantan-1-carbonyl chloride. Because of that, the isotope analysis with labelled H2[18O] was performed. The required labelled [18O]adamantan-1-carbonyl chloride was prepared according to Scheme 1. Maximum available labelling of acylchloride (~50% from ~100% labelled water) was sufficient for ESI MS analysis. Analysing the protonated molecular peak of isolated isochromanone, it was determined that only one labelled oxygen originate from adamantan-1-carbonyl chloride. We have tried to locate specific position of the labelling using tandem mass spectra. Surprisingly, it was found that the labelling was redistributed between b
Czech name
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Czech description
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Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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