The Fischer indolisation of N-(?-ketoacyl)anthranilic acids

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F12%3A43869047" target="_blank" >RIV/70883521:28110/12:43869047 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
The Fischer indolisation of N-(?-ketoacyl)anthranilic acids
Original language description
As a part of our continued interest in the reactivity of title compounds toward various reagents, we have studied Fischer indole reaction starting from appropriate phenylhydrazones as well as one-pot protocol starting from N-(?-ketoacyl)anthranilic acids. One of our ideas was to find a novel route to 2-(indol-2-carboxamido)benzoic acids as starting materials for subsequent cyclodehydration leading to appropriate 2-(indol-2-yl)-3,1-benzoxazin-4-ones. We realized that Fischer indole reaction of title compounds leads to three kinds of products, including desired 2-(indol-2-carboxamido)benzoic acids, their phenylhydrazides, and the mentioned benzoxazinones. Various derivatives of 2-(indol-2-carboxamido)benzoic acids can exhibit biological activity and someof them were isolated from nature. Substituted 3,1-benzoxazin-4-ones are interesting heterocyclic compounds, which may find application as novel therapeutic agents, agrochemicals, industrial additives or intermediates in organic synthese
Czech name
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Czech description
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Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Sborník abstraktů: studentská odborná konference Chemie je život 2012
ISBN
978-80-214-4645-8
ISSN
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e-ISSN
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Number of pages
5
Pages from-to
409-414
Publisher name
Vysoké učení technické v Brně, Fakulta chemická
Place of publication
Brno
Event location
Brno
Event date
Dec 7, 2012
Type of event by nationality
CST - Celostátní akce
UT code for WoS article
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