Synthesis of Novel Purine Ribonucleosides Bearing Adamantane Moiety
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F13%3A43870138" target="_blank" >RIV/70883521:28110/13:43870138 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Synthesis of Novel Purine Ribonucleosides Bearing Adamantane Moiety
Original language description
Purine nucleosides represent one of the most extensive class of nitrogen heterocycles in the nature with a wide spectrum of significant biological effects. They can act as adenosine receptor ligands, inhibitors of nucleoside transport or antifungal, antiviral and antitumor agents. In this work, several novel purine ribonucleosides bearing a unique adamantylated amines in the 6-position were synthesized in multi-step procedure from starting commercially available hypoxanthine and D-(?)-ribose. Adamantylated aromatic amines were prepared following previously published procedure. The introduction of highly lipophilic adamantyl moiety into the purine pharmacophore can lead to the interesting pharmacological profile of final molecules. All prepared compounds were fully characterised using spectral methods.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
CC - Organic chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů