Preparation of new adamantylated purine ribonucleosides
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F15%3A43873270" target="_blank" >RIV/70883521:28110/15:43873270 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Preparation of new adamantylated purine ribonucleosides
Original language description
Purine ribonucleosides represent one of the most extensive class of nitrogen heterocycles in the nature. A wide range of interesting biological effects of these compounds, such as inhibition of nucleoside transport or antifungal, antiviral and antitumoractivities, is described in the literature. In this work, several novel purine ribonucleosides bearing unique adamantylated amines in the 6-position were synthesized employing a multi-step approach based on sequence of a nucleophilic aromatic substitution, a glycosylation and a deprotection of ribofuranose unit, as it is depicted in Figure 1. Adamantylated aromatic amines introduced at C6 of the purine ring were prepared following previously published procedure. All prepared compounds were obtained in good yields and purity. Their structures were confirmed using spectral methods, e.g. IR, MS and NMR, respectively.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
CC - Organic chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů