Effect of vehicle on the performance of active moisturizing substances

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F15%3A43873248" target="_blank" >RIV/70883521:28110/15:43873248 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1111/srt.12206" target="_blank" >http://dx.doi.org/10.1111/srt.12206</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/srt.12206" target="_blank" >10.1111/srt.12206</a>

Result language
angličtina
Original language name
Effect of vehicle on the performance of active moisturizing substances
Original language description
Purpose: The work is aimed at the description and study of the hydration effect of different active substances (hyaluronic acid, sericin, glycerol, and urea) incorporated in two different vehicles commonly used for compounding pharmaceutical ingredients,gel, and emulsion. Methods: The effects of the formulations were investigated by instrumental methods in vivo after their administration to the skin of volar forearms in a group of 20 healthy volunteers (women, mean age of 28 years). Hydration effect was observed by corneometry and barrier properties (TEWL) by tewametr at regular time intervals (1-26 h) after application of the prepared samples. Results: The results indicate that the active substances incorporated in the emulsion moisturize the skin better compared to the same substances contained in the gel. Furthermore, it was found that these ingredients, whether they are present in the emulsion or in the gel, prevent TEWL in a similar manner. Conclusion: The study showed that diffe
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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