Transdermal absorption of active substances from cosmetic vehicles
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F19%3A63523419" target="_blank" >RIV/70883521:28110/19:63523419 - isvavai.cz</a>
Alternative codes found
RIV/70883521:28610/19:63523419
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/full/10.1111/jocd.12873" target="_blank" >https://onlinelibrary.wiley.com/doi/full/10.1111/jocd.12873</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/jocd.12873" target="_blank" >10.1111/jocd.12873</a>
Alternative languages
Result language
angličtina
Original language name
Transdermal absorption of active substances from cosmetic vehicles
Original language description
Background:Cosmetic products mean any substance or mixture intended to be placed in contact with the external parts of the human body (eg, epidermis, lips) and should not pass to the lower parts and penetrate to the skin. As a part of evaluation of cosmetic safety, the transdermal absorption of substances should be investigated. Materials and Methods: In vitro absorption was investigated with Franz diffusion cells on untreated porcine skin and specimens of the same treated with 15%wt. SLS. The integrity of the skin was discerned by gauging transdermal electrical conductivity (TEC), the concentration of caffeine absorbed by the samples of skin membrane by liquid chromatography, which took place by applying an emulsion and/or a gel containing active hydration agents (urea, sodium hyaluronate, and sericin). Results: The greatest extent of caffeine penetration was seen for pretreatment with just SLS; similar results were in skin treated with the base gel with 10%wt. urea. In the skin treated with the base emulsion only, the amount of caffeine absorbed was twofold less; this increased after adding the active hydration substances. The values measured for TEC corresponded with the amount of caffeine absorbed. Conclusion: The gel proved to be the more potent vehicle for the active ingredient, as it demonstrated greater transdermal caffeine penetration than the emulsions, correlating with the degree of damage to the skin as detected by TEC.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30216 - Dermatology and venereal diseases
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Cosmetic Dermatology
ISSN
1473-2130
e-ISSN
—
Volume of the periodical
18
Issue of the periodical within the volume
5
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
1410-1415
UT code for WoS article
000489743100036
EID of the result in the Scopus database
2-s2.0-85061000178