In vivo efficacy and properties of semisolid formulations containing panthenol

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F19%3A63523417" target="_blank" >RIV/70883521:28110/19:63523417 - isvavai.cz</a>

Alternative codes found

RIV/70883521:28610/19:63523417

Result on the web

<a href="https://onlinelibrary.wiley.com/doi/full/10.1111/jocd.12527" target="_blank" >https://onlinelibrary.wiley.com/doi/full/10.1111/jocd.12527</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/jocd.12527" target="_blank" >10.1111/jocd.12527</a>

Result language

angličtina

Original language name

In vivo efficacy and properties of semisolid formulations containing panthenol

Original language description

Background Panthenol is an active substance used in dermatology to protect the health of the skin, to treat defects in the morphology of the stratum corneum. In cosmetology, hydrating, softening, and barrier function of panthenol are utilized. Detailed studies evaluating the efficacy of panthenol in cosmetic and pharmaceutical semisolid formulations and establishing its optimum concentration are needed. Objectives To investigate whether an addition of 5-13 wt% panthenol in o/w and w/o emulsions increases hydration and supports the barrier properties of the skin. Rheological properties and sensory analysis of prepared formulations are supplemented. Methods Noninvasive instrumental methods in vivo were used. The hydration and barrier effect of semisolid formulations on the skin were observed for 48 hour; testing was conducted on 40 women. The effect was compared with formulations without any content of panthenol. The rheological and organoleptic properties of the formulations were evaluated. Results After applying either form of the formulations containing 7-11 wt% of panthenol hydration of the skin increased, transepidermal water loss decreased. pH of the skin shifted toward neutral after application of tested formulations. The rheological properties of the formulations were influenced by the type of vehicle, the amount of panthenol, and temperature. Sensory evaluation of both semisolid forms revealed statistically significant differences in o/w formulations with regard to spreadability. Conclusions The presence of panthenol in an o/w and w/o semisolid formulations significantly enhances skin barrier repair and hydration of the stratum corneum. Better vehicle for the active substance as regards hydration proved o/w formulations.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30216 - Dermatology and venereal diseases

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Cosmetic Dermatology

ISSN

1473-2130

e-ISSN

—

Volume of the periodical

18

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

346-354

UT code for WoS article

000457464700054

EID of the result in the Scopus database

2-s2.0-85044347774