The cosmetic and dermatological potential of keratin hydrolysate

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F17%3A63517066" target="_blank" >RIV/70883521:28110/17:63517066 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1111/jocd.12319" target="_blank" >http://dx.doi.org/10.1111/jocd.12319</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/jocd.12319" target="_blank" >10.1111/jocd.12319</a>

Result language

angličtina

Original language name

The cosmetic and dermatological potential of keratin hydrolysate

Original language description

Background: Although keratin hydrolysates have become established as standard components in hair and nail cosmetics, studies on the moisturizing effects of keratin hydrolysates do not appear among contemporary literature. Objectives: To test if adding keratin hydrolysate into an ointment base increases hydration of the skin and improves skin barrier function, or diminishes trans-epidermal water loss. Methods: Formulations were prepared containing 2%, 4%, and 6% keratin hydrolysates (based on weight of the ointment base). The moisturizing properties of keratin hydrolysates were tested by measuring skin hydration, trans-epidermal water loss and skin pH; measurements were carried out at intervals of 1, 2, 3, 4, 24, and 48 h. Testing was conducted on 10 women. Results: As regards hydration, adding 2% keratin hydrolysate to the ointment base is optimal, as an increase of 14%-23% occurs in hydration of the stratum corneum. For trans-epidermal water loss, adding 4% KH to the ointment base is preferential, as this triggers a 26%-46% decrease in trans-epidermal water loss. Conclusions: Keratin hydrolysate acts as a humectant (it binds water from lower layers of the epidermis to the stratum corneum) as well as an occlusive (it reduces trans-epidermal water loss). The highly favorable properties of keratin hydrolysates are attributed to the wide distribution of keratin hydrolysates molecular weights; low-molecular weight fractions easily penetrate the SC, while high-molecular weight fractions form a protective film on the epidermis. Adding keratin hydrolysates to the ointment base did not cause phase separation even after 6 mo storage.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30216 - Dermatology and venereal diseases

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Cosmetic Dermatology

ISSN

1473-2130

e-ISSN

—

Volume of the periodical

16

Issue of the periodical within the volume

4

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

"e21"-"e27"

UT code for WoS article

000416913500004

EID of the result in the Scopus database

2-s2.0-85012877459