Determination of Selenium Species by ICP-MS Method in Biological Samples

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F16%3A43875290" target="_blank" >RIV/70883521:28110/16:43875290 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Determination of Selenium Species by ICP-MS Method in Biological Samples

Original language description

The opinion on selenium influence on human organism has varied in the course of the past century. At first, selenium was considered to be badly toxic up to cancerogenic. As time went by, it was discovered to have an essential role in human organism. In human organism selenium is a part of many enzyme systems, e.g. glutathione peroxidase, and as a part of antioxidant defense system it has an expressive preventive effect against cardiovascular and oncogenic diseases. The toxicity of selenium doesn't only depend on its amount but also on its chemical form or species (oxidation state, organic or inorganic form, eventually the occurrence of single isotopes) and that is why the compounds speciation becomes unavoidable. Many laboratories deal with speciation analysis of various elements, one of which is selenium. Various studies are used in various analytical methods (typically in an online ordering) for the determination of different forms of selenium. However, as the most suitable, in terms of achieving very low detection limits, appears combination HPLC/IC-ICP-MS. In this work are shown the possibilities of this application, recently reported methods for the analysis of various forms of selenium compounds in biological materials [1, 2]. Analytical chemists have increasingly realized that determining total contents of the elements cannot provide the required information about mobility, bioavailability, and finally the impact of elements on ecological systems or biological organisms. Only knowledge about the chemical species of the elements can lead to understanding of chemical and biochemical reactions involving these species, thus providing information about toxicity or essentiality. This is why speciation analysis has become an essential tool for risk assessment of elements in the environment, leading to more effective diagnosis and therapy, to understanding the toxicity and the moving of trace elements and to better nutrition and health.

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

CB - Analytical chemistry, separation

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů