Selectively oxidized cellulose with adjustable molecular weight for controlled release of platinum anticancer drugs

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F19%3A63523467" target="_blank" >RIV/70883521:28110/19:63523467 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/19:00107804 RIV/70883521:28610/19:63523467 RIV/00216208:11110/19:10409260

Result on the web

<a href="https://pubs.acs.org/doi/10.1021/acs.biomac.8b01807" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.biomac.8b01807</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.biomac.8b01807" target="_blank" >10.1021/acs.biomac.8b01807</a>

Result language

angličtina

Original language name

Selectively oxidized cellulose with adjustable molecular weight for controlled release of platinum anticancer drugs

Original language description

The synthesis of selectively oxidized cellulose, 2,3-dicarboxycellulose (DCC), is optimized for preparation of highly oxidized material for biological applications, which includes control over the molecular weight of the product during its synthesis. Conjugates of DCC and cisplatin simultaneously offer a very high drug binding efficiency (&gt;90%) and drug loading capacity (up to 50 wt %), while retaining good aqueous solubility. The adjustable molecular weight of the DCC together with variances in drug feeding ratio allows to optimize cisplatin release profiles from delayed (&lt;2% of cisplatin released during 6 h) to classical burst release with more than 60% of cisplatin released after 24 h. The release rates are also pH-dependent (up to 2 times faster release at pH 5.5 than at pH 7.4), which allows to exploit the acidic nature of tumor microenvironment. Extensive in vitro studies were performed on eight different cell lines for two cisplatin-DCC conjugates with different release profiles. In comparison with free cisplatin, both cisplatin-DCC conjugates demonstrated considerably lower cytotoxicity toward healthy cells. Conjugates with burst release profiles were found more effective against prostate cell lines, while DCC conjugates with slower release were more cytotoxic against ovarian and lung carcinoma cell lines. In vivo studies indicated a significantly longer survival rate, a reduction in tumor volume, and a higher accumulation of platinum in tumors of mice treated with the cisplatin-DCC conjugate in comparison to those treated by free cisplatin.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10404 - Polymer science

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomacromolecules

ISSN

1525-7797

e-ISSN

—

Volume of the periodical

20

Issue of the periodical within the volume

Neuveden

Country of publishing house

US - UNITED STATES

Number of pages

12

Pages from-to

1623-1634

UT code for WoS article

000464248300015

EID of the result in the Scopus database

2-s2.0-85063044087