Enhancing cisplatin anticancer effectivity and migrastatic potential by modulation of molecular weight of oxidized dextran carrier

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F21%3A00119604" target="_blank" >RIV/00216224:14110/21:00119604 - isvavai.cz</a>
Alternative codes found
RIV/70883521:28610/21:63543918 RIV/00216208:11110/21:10432405
Result on the web
<a href="https://reader.elsevier.com/reader/sd/pii/S0144861721008481?token=6B980116FFE89BE9644D630E5871F9E438C2A85EC19DD545C3ABE52B8108EA349F2BD805D3531CE612288A0775CE71A2&originRegion=eu-west-1&originCreation=20220124064804" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S0144861721008481?token=6B980116FFE89BE9644D630E5871F9E438C2A85EC19DD545C3ABE52B8108EA349F2BD805D3531CE612288A0775CE71A2&originRegion=eu-west-1&originCreation=20220124064804</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.carbpol.2021.118461" target="_blank" >10.1016/j.carbpol.2021.118461</a>

Result language
angličtina
Original language name
Enhancing cisplatin anticancer effectivity and migrastatic potential by modulation of molecular weight of oxidized dextran carrier
Original language description
The molecular weight (M-w) of dextran derivatives, such as regioselectively oxidized dicarboxydextran (DXA), is greatly influencing their faith in an organism, which could be possibly used to improve anticancer drug delivery. Here we present a modified method of sulfonation-induced chain scission allowing direct and accurate control over the M-w of DXA without increasing its polydispersity. Prepared DXA derivatives (M-w = 10-185 kDa) have been conjugated to cisplatin and the M-w of the carrier found to have a significant impact on cisplatin release rates, in vitro cytotoxicity, and migrastatic potential. Conjugates with the high-M-w DXA showed particularly increased anticancer efficacy. The best conjugate was four times more effective against malignant prostatic cell lines than free cisplatin and significantly inhibited the ovarian cancer cell migration. This was traced to the characteristics of spontaneously formed cisplatin-crosslinked DXA nanogels influenced by M-w of DXA and amount of loaded cisplatin.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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