Self-assembled Oxidized Dextran Nanogels for Cisplatin Delivery

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F23%3A63574938" target="_blank" >RIV/70883521:28610/23:63574938 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
Self-assembled Oxidized Dextran Nanogels for Cisplatin Delivery
Original language description
Cisplatin (CP, cis-[Pt(NH3)2Cl2]) is a first-line chemotherapeutic used for patients diagnosed with various types of cancer. However, its use is accompanied by neuro-, nephro- and ototoxicity as a result of its nonspecific action. The CP conjugation to polysaccharides advantageously reduce off-toxicity, protect the conjugated CP and improve accumulation in tumor (enhanced permeability and retention effect). Dextrans are a-(1 ➔6) glucans with a-(1 ➔3) branching and are used as plasma vol ume expanders, antithrombotic agents etc. Dicarboxylated dextran (DXA) prepared via sequential periodate-chlorite oxidation was conjugated with CP and showed highest overall cellular uptake and high toxicity towards malignant cell lines among the other dicaboxylated polysaccharide-CP conjugates. Furthermore, the migrastatic and anticancer efficacy was found to be dependent on the formation of CP-DXA nano-assembliesY1 Thus, the DXA macromolecules containing high -COOH group density were crosslinked via CP bidentate binding to form CP-DXA nanogels and their physico-chemical and biological properties evaluated.
Czech name
—
Czech description
—

Type
O - Miscellaneous
CEP classification
—
OECD FORD branch
20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)