Biocompatible dialdehyde cellulose/poly(vinyl alcohol) hydrogels with tunable properties

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F19%3A63523492" target="_blank" >RIV/70883521:28110/19:63523492 - isvavai.cz</a>
Alternative codes found
RIV/70883521:28610/19:63523492
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0144861719304837" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0144861719304837</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.carbpol.2019.04.091" target="_blank" >10.1016/j.carbpol.2019.04.091</a>

Result language
angličtina
Original language name
Biocompatible dialdehyde cellulose/poly(vinyl alcohol) hydrogels with tunable properties
Original language description
Solubilized dialdehyde cellulose (DAC), an efficient crosslinking agent for poly(vinyl alcohol)(PVA), provides less toxic alternative to current synthetic crosslinking agents such as glutaraldehyde, while simultaneously allowing for the preparation of hydrogels with comparably better characteristics. PVA/DAC hydrogels prepared using 0.5, 1 and 1.5 wt% of DAC were analyzed in terms of mechanical, swelling and cytotoxicity characteristics. Materials properties of PVA/DAC hydrogels range from stiff substances to soft viscoelastic gels capable of holding large amounts of water. Superior mechanical properties, porosity and surface area in comparison with analogical PVA/glutaraldehyde hydrogels were observed. Biological studies showed low toxicity and good biocompatibility of PVA/DAC hydrogels. Potential of PVA/DAC in mesh-controlled release of biologically active compounds was investigated using ibuprofen, rutin and phenanthriplatin. Hydrogel loaded with anticancer drug phenantriplatin was found effective against alveolar cancer cell line A549 under in vitro conditions.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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