Utilization of Dialdehyde Cellulose as Crosslinker for Poly(vinyl alcohol)
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F19%3A63524203" target="_blank" >RIV/70883521:28110/19:63524203 - isvavai.cz</a>
Alternative codes found
RIV/70883521:28610/19:63524203
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Utilization of Dialdehyde Cellulose as Crosslinker for Poly(vinyl alcohol)
Original language description
Crosslinking agents based on modified biopolymers are particularly favorable in biomedical sector as alternatives to toxic synthetic low-molecular weight crosslinkers (i.e. glutaraldehyde). Periodate oxidation of cellulose produces dialdehyde cellulose (DAC) which can be solubilized1 and used as crosslinker for poly(vinyl alcohol) (PVA).2 Solubilization is recognized as key step influencing molecular weight of DAC.3 Furthermore, due to high reactivity of aldehyde groups (–CHO), DAC decays in time.1 Nevertheless, DAC can be stabilized for several weeks when kept at low pH.3 The reactive DAC species form hemiacetal bonds with hydroxyl groups of PVA in presence of acid catalyst. In contrast to low molecular crosslinker-based hydrogels, resulting network presumably possesses very different crosslink topology and lower toxicity arising from the DAC macromolecular character.2,4 PVA/DAC materials may found application in pharmaceutics as materials for wound dressing or drug release. The scope of this study was to utilize a broad range of concentrations of solubilized DAC and glutaraldehyde (GA) in PVA hydrogel formation and evaluate their efficiency.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
20901 - Industrial biotechnology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů