Large Amplitude Oscillatory Shear Tests of Pressure Sensitive Adhesives Designed for Transdermal Therapeutic Systems

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F20%3A63527076" target="_blank" >RIV/70883521:28110/20:63527076 - isvavai.cz</a>

Alternative codes found

RIV/70883521:28610/20:63527076

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Large Amplitude Oscillatory Shear Tests of Pressure Sensitive Adhesives Designed for Transdermal Therapeutic Systems

Original language description

Transdermal Therapeutic Systems (TTS) based on pressure sensitive adhesives (PSA) allow for application of pharmaceutical substances via diffusion through the skin. Rheological performance of PSA is largely investigated within small amplitude oscillatory shear (typically up to 1 %), although the skin motions exceed strains beyond 40 %. In this paper, amine compatible (AC) and non-amine compatible (NAC) silicone based PSA compounds differing in the resin content were subjected to strain amplitude sweeps in a twin drive rheometer. Carreau-Yasuda-like fitting of storage and loss moduli curves intercept the substantial effect of resin content on both compounds; up to four-times higher moduli of AC compounds were determined in SAOS, and their higher molecular mass combined with enhanced interactions contributed to an earlier transition to nonlinear viscoelastic region. In the nonlinear range, elastic and viscous properties are affected by strains in a different manner with the trend favorable for the PSA application as TTS. Importantly, the nonlinear coefficient Q(γ_0 ) was found to be inappropriate to quantify nonlinear behavior for PSA. Instead, the third relative higher harmonic from Fourier transformation I_(3/1) as well as intra-cycle strain stiffening and shear thickening ratios provide information relevant for an optimization of PSA subjected to large deformations.

Czech name

—

Czech description

—

Type

O - Miscellaneous

CEP classification

—

OECD FORD branch

10404 - Polymer science

Project

<a href="/en/project/LO1504" target="_blank" >LO1504: Centre of Polymer Systems Plus</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů