Preparation and characterization of injectable self-antibacterial gelatin/carrageenan/bacterial cellulose hydrogel scaffolds for wound healing application

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F21%3A63528378" target="_blank" >RIV/70883521:28110/21:63528378 - isvavai.cz</a>

Alternative codes found

RIV/70883521:28610/21:63528378

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S1773224721000952" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1773224721000952</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jddst.2021.102415" target="_blank" >10.1016/j.jddst.2021.102415</a>

Result language

angličtina

Original language name

Preparation and characterization of injectable self-antibacterial gelatin/carrageenan/bacterial cellulose hydrogel scaffolds for wound healing application

Original language description

This study reports the preparation of self-crosslinked Schiff base gels using gelatin and oxidized carrageenan gum interpenetrated with bacterial cellulose (BC) as injectable drug delivery systems. The injectable gels were successfully prepared at body temperature upon blending with BC and loaded with bovine serum albumin (as the model drug) to produce scaffolds. The gel scaffolds were characterized via rheological, FTIR, SEM, XRD, TGA and mechanical compression analysis. Gelation kinetics of gels as well as swelling, in vitro degradation and drug release kinetics of gel scaffolds were examined. Results showed that the incorporation of BC to the gel system considerably improved mechanical integrity with remarkable rheological shear-thinning properties. Maximum in vitro cumulative drug release from gel scaffolds was determined as 84.01 ± 3.66% within the studied time interval of 168 h. Further analysis showed that the prepared gel scaffolds possess self-antibacterial properties with growth inhibition capacity against E. coli, S. aureus, and K. pneumonia. In vitro cell cytotoxicity was also performed by MTT assay and results depicted &gt;80% cell viability, which indicates the gel scaffolds are cytocompatible. In conclusion, this paper presents a facile approach to fabricate all-natural crosslinked injectable self-antibacterial gels systems with prospective potential application in wound dressing and tissue regeneration.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials

Project

<a href="/en/project/TH71020005" target="_blank" >TH71020005: Bioactive injectable hydrogels for soft tissue regeneration after reconstructive maxillofacial surgeries</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Drug Delivery Science and Technology

ISSN

1773-2247

e-ISSN

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Volume of the periodical

63

Issue of the periodical within the volume

Neuveden

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

12

Pages from-to

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UT code for WoS article

000670348300006

EID of the result in the Scopus database

2-s2.0-85101615231