Effect of saccharides coating on antibacterial potential and drug loading and releasing capability of plasma treated polylactic acid films
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F22%3A63556818" target="_blank" >RIV/70883521:28110/22:63556818 - isvavai.cz</a>
Alternative codes found
RIV/70883521:28610/22:63556818
Result on the web
<a href="https://www.mdpi.com/1422-0067/23/15/8821" target="_blank" >https://www.mdpi.com/1422-0067/23/15/8821</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms23158821" target="_blank" >10.3390/ijms23158821</a>
Alternative languages
Result language
angličtina
Original language name
Effect of saccharides coating on antibacterial potential and drug loading and releasing capability of plasma treated polylactic acid films
Original language description
More than half of the hospital-associated infections worldwide are related to the adhesion of bacteria cells to biomedical devices and implants. To prevent these infections, it is crucial to modify biomaterial surfaces to develop the antibacterial property. In this study, chitosan (CS) and chondroitin sulfate (ChS) were chosen as antibacterial coating materials on polylactic acid (PLA) surfaces. Plasma-treated PLA surfaces were coated with CS either direct coating method or the carbodiimide coupling method. As a next step for the combined saccharide coating, CS grafted samples were immersed in ChS solution, which resulted in the polyelectrolyte complex (PEC) formation. Also in this experiment, to test the drug loading and releasing efficiency of the thin film coatings, CS grafted samples were immersed into lomefloxacin-containing ChS solution. The successful modifications were confirmed by elemental composition analysis (XPS), surface topography images (SEM), and hydrophilicity change (contact angle measurements). The carbodiimide coupling resulted in higher CS grafting on the PLA surface. The coatings with the PEC formation between CS-ChS showed improved activity against the bacteria strains than the separate coatings. Moreover, these interactions increased the lomefloxacin amount adhered to the film coatings and extended the drug release profile. Finally, the zone of inhibition test confirmed that the CS-ChS coating showed a contact killing mechanism while drug-loaded films have a dual killing mechanism, which includes contact, and release killing.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20506 - Coating and films
Result continuities
Project
<a href="/en/project/GA20-28732S" target="_blank" >GA20-28732S: Colloidal systems for topical formulations. Pickering emulsions and polymer based colloids.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Molecular Sciences
ISSN
1661-6596
e-ISSN
1422-0067
Volume of the periodical
23
Issue of the periodical within the volume
15
Country of publishing house
CH - SWITZERLAND
Number of pages
19
Pages from-to
nestrankovano
UT code for WoS article
000839087700001
EID of the result in the Scopus database
2-s2.0-85136340247