Whey protein isolate-chitosan PolyElectrolyte Nanoparticles as a drug delivery system
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F23%3A63566818" target="_blank" >RIV/70883521:28110/23:63566818 - isvavai.cz</a>
Alternative codes found
RIV/70883521:28610/23:63566818
Result on the web
<a href="https://www.mdpi.com/1420-3049/28/4/1724" target="_blank" >https://www.mdpi.com/1420-3049/28/4/1724</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/molecules28041724" target="_blank" >10.3390/molecules28041724</a>
Alternative languages
Result language
angličtina
Original language name
Whey protein isolate-chitosan PolyElectrolyte Nanoparticles as a drug delivery system
Original language description
Whey protein isolate (WPI), employed as a carrier for a wide range of bioactive substances, suffers from a lack of colloidal stability in physiological conditions. Herein, we developed innovative stabilized PolyElectrolyte Nanoparticles (PENs) obtained by two techniques: polyelectrolyte complexation of negatively charged WPI and positively charged chitosan (CS), and ionic gelation in the presence of polyanion tripolyphosphate (TPP). Therefore, the WPI-based core was coated with a CS-based shell and then stabilized by TPP at pH 8. The nanostructures were characterized by physiochemical methods, and their encapsulation efficiency and in vitro release were evaluated. The spherical NPs with an average size of 248.57 +/- 5.00 nm and surface charge of +10.80 +/- 0.43 mV demonstrated high encapsulation efficiency (92.79 +/- 0.69) and sustained release of a positively charged chemotherapeutic agent such as doxorubicin (DOX). Z-average size and size distribution also presented negligible increases in size and aggregates during the three weeks. The results obtained confirm the effectiveness of the simultaneous application of these methods to improve the colloidal stability of PEN.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecules
ISSN
1420-3049
e-ISSN
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Volume of the periodical
28
Issue of the periodical within the volume
4
Country of publishing house
CH - SWITZERLAND
Number of pages
12
Pages from-to
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UT code for WoS article
000941722100001
EID of the result in the Scopus database
2-s2.0-85149053047