Chitosan-whey protein isolate core-shell nanoparticles as delivery systems

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F23%3A63574720" target="_blank" >RIV/70883521:28610/23:63574720 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Chitosan-whey protein isolate core-shell nanoparticles as delivery systems
Original language description
Whey protein isolate (WPI), employed as a camer for a wide range of bioactive substances, suffers from a lack of colloidal stability in physiological conditions. Herein, we developed innovative stabilized Poly Electrolyte Nanoparticles (PENs) obtained by two techniques: polyelectrolyte complexation of negatively charged WPI and positively charged chitosan (GS), and ionic gelation in the presence of polyanion tripolyphosphate (TPP). Therefore, the WPl-based core was coated with a CS-based shell and then stabilized by TPP al pH 8. The nanostructures were characterized by physiochemical methods, and lheir encapsulation efficiency and in vitro release were evaluated. The spherical NPs with an average size of 248. 57 ± 5.00 nm and surface charge of +10.80 ± 0.43 mV demonstrated high encapsulation efficiency (92. 79 ± 0.69) and sustained release of a positively charged chemotherapeutic agent of doxorubicin (DOX) as model drug .
Czech name
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Czech description
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Type
O - Miscellaneous
CEP classification
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OECD FORD branch
20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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