Design and fabrication of electrospun PLA-based silica-modified composite nanofibers with antibacterial properties for perspective wound treatment
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F23%3A63569603" target="_blank" >RIV/70883521:28110/23:63569603 - isvavai.cz</a>
Alternative codes found
RIV/70883521:28610/23:63569603
Result on the web
<a href="https://www.mdpi.com/2073-4360/15/17/3500" target="_blank" >https://www.mdpi.com/2073-4360/15/17/3500</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/polym15173500" target="_blank" >10.3390/polym15173500</a>
Alternative languages
Result language
angličtina
Original language name
Design and fabrication of electrospun PLA-based silica-modified composite nanofibers with antibacterial properties for perspective wound treatment
Original language description
The aim of this study was to develop a novel amikacin (AMI) delivery system with prolonged release based on composite electrospun nanofibers of PLA supplemented with AMI-loaded Si nanoparticles of different morphology. The resultant materials were characterized in terms of their physical properties (scanning electron microscopy, Brunauer-Emmett-Teller analysis, thermogravimetric analysis, water contact angle). High-Performance Liquid Chromatography was used to determine the AMI content in the liquid fractions obtained from the release study. The results show that nanofibers of fumed silica exhibited an aggregated, highly porous structure, whereas nanofibers of mesoporous silica had a spherical morphology. Both silica nanoparticles had a significant effect on the hydrophilic properties of PLA nanofiber surfaces. The liquid fractions were investigated to gauge the encapsulation efficiency (EE) and loading efficiency (LE) of AMI, demonstrating 66% EE and 52% LE for nanofibers of fumed silica compared to nanofibers of mesoporous silica nanoparticles (52% EE and 12.7% LE). The antibacterial activity of the AMI-loaded nanofibers was determined by the Kirby-Bauer Method. These results demonstrated that the PLA-based silica nanofibers effectively enhanced the antibacterial properties against the Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Polymers
ISSN
2073-4360
e-ISSN
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Volume of the periodical
15
Issue of the periodical within the volume
17
Country of publishing house
CH - SWITZERLAND
Number of pages
16
Pages from-to
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UT code for WoS article
001061156500001
EID of the result in the Scopus database
2-s2.0-85170370757