Carbonyl Iron Grafted with 2-Isopropenyl-2-oxazoline under Atom Transfer Radical Polymerization Conditions in Solution

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F23%3A63571039" target="_blank" >RIV/70883521:28110/23:63571039 - isvavai.cz</a>
Alternative codes found
RIV/70883521:28610/23:63571039
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Carbonyl Iron Grafted with 2-Isopropenyl-2-oxazoline under Atom Transfer Radical Polymerization Conditions in Solution
Original language description
The poly(2-isopropenyl-2-oxazoline) (PIPOx) is considered as a promising polymer for biomedical applications. The in-vitro cytotoxicity measurements and ex-vivo proliferation tests proved non-cytotoxicity of PIPOx. IPOx monomer provides two polymerizable groups, the vinyl and 2-oxazoline unit. In this study the attention was paid to polymerization using the vinyl group. The utilization of ATRP technique allows to obtain the well-defined polymers. However, the attempts to polymerize IPOx under traditional ATRP conditions were described as unsuccessful due to strong complexation of pendant 2-oxazoline group with copper catalyst. In this contribution it is shown that IPOx can be polymerized under ATRP conditions when copper bromide is replaced with copper chloride. In addition, the surface-initiated ATRP from the carbonyl iron (CI) particles was employed by halogen exchange method for the first time. The fabricated CI-PIPOx hybrids were thoroughly characterized and both magnetorheological capabilities of the hybrid particles in blood-like medium as well as their cytocompatibility behaviour showed promising results for possible application as embolization agent.
Czech name
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Czech description
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Project
<a href="/en/project/NU23-08-00243" target="_blank" >NU23-08-00243: Functional replacements for nerve tissue regeneration fabricated using advanced 3D printing techniques</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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