RheoTack evaluation of detaching behavior of silicone-based pressure sensitive adhesives for transdermal therapeutic systems

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F25%3A63594740" target="_blank" >RIV/70883521:28110/25:63594740 - isvavai.cz</a>

Alternative codes found

RIV/70883521:28610/25:63594740

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S026322412500795X?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S026322412500795X?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.measurement.2025.117436" target="_blank" >10.1016/j.measurement.2025.117436</a>

Result language

angličtina

Original language name

RheoTack evaluation of detaching behavior of silicone-based pressure sensitive adhesives for transdermal therapeutic systems

Original language description

This study focuses on applying the RheoTack method to assess the detaching behavior of transdermal therapeutic systems (TTS), which represent skin-applied medications comprising a drug-loaded pressure-sensitive adhesive (PSA) and a flexible backing layer. The RheoTack method provides detailed force-retraction displacement-curves (F-h-curves) that reveal the influence of chemical structure and resin content on PSA deformation and fibril formation. To compare various rod geometries (flat rods with diameters of 5 mm and 8 mm, and a spherically rounded rod with a contact area of 5 mm2), the force-retraction displacement curves were normalized to account for the effective contact areas. The flat and spherical rods led to completely different F-h-curves as well as different failure and tack behaviors. Furthermore, the adhesion formation between the TTS with flexible backing layers and rods during the dwell phase occurs in a different manner compared with rigid plates, particularly for flat rods, where maximum compression stresses occur at the edges and not uniformly over the cross-section. Measurements of F-h-curves were performed with retraction speeds of 0.01, 0.1, and 1 mm/s. The increase in retraction speed increased the stiffness from 250 to 1200 N/m for non-amine-compatible PSA measured with a rod of 8 mm. RheoTack measurements were performed with a dwell time of 1 s, which is consistent with ASTM D2949. However, the TTS was in the adhesion-establishing compression phase for 3 s at 1 mm/s and for 30 s at 0.01 mm/s. Thus, the approach to follow ASTM D2949 has to be reconsidered for testing TTS materials.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

20302 - Applied mechanics

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Measurement

ISSN

0263-2241

e-ISSN

—

Volume of the periodical

253

Issue of the periodical within the volume

Part A

Country of publishing house

GB - UNITED KINGDOM

Number of pages

13

Pages from-to

nestránkováno

UT code for WoS article

001463102300001

EID of the result in the Scopus database

2-s2.0-105001736708