Antibacterial Polyvinyl Chloride/Antibiotic Films: The Effect of Solvent on Morphology, Antibacterial Activity, and Release Kinetics

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F10%3A63509211" target="_blank" >RIV/70883521:28610/10:63509211 - isvavai.cz</a>

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Antibacterial Polyvinyl Chloride/Antibiotic Films: The Effect of Solvent on Morphology, Antibacterial Activity, and Release Kinetics

Original language description

Medical-grade polyvinyl chloride was modified with sodium ampicillin in a concentration range from 0 to 5 wt % by solvent casting technique using cyclohexanone and N,N-dimethylformamide. The obtained polymeric systems were characterized by optical microscopy, tensile test, and scanning electron microscopy. In addition, in vitro antibacterial activity against Gram-negative and Gram-positive bacteria were determined by an agar diffusion test. Antibiotic release experiments were performed in distilled water and physiological saline solution, which were monitored by UV-vis spectroscopy. The results showed a crucial role of the solvent on the morphology, antibacterial activity, and releasing characteristic of the ampicillin. Furthermore, a mathematical model was applied to data obtained from release study, to characterize the release kinetics of the ampicillin from the polyvinyl chloride-antibiotic systems.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CD - Macromolecular chemistry

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Applied Polymer Science

ISSN

0021-8995

e-ISSN

—

Volume of the periodical

118

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

—

UT code for WoS article

—

EID of the result in the Scopus database

—