Partial Hydrolysis of Poly(2-ethyl-2-oxazolines) to Poly(2-oxazoline-co-ethylene imines): Synthesis, Cytotoxicity and Complexing Efficiency with the Perspective for Biomedical Applications
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F13%3A43870732" target="_blank" >RIV/70883521:28610/13:43870732 - isvavai.cz</a>
Alternative codes found
RIV/70883521:28110/13:43870732
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Partial Hydrolysis of Poly(2-ethyl-2-oxazolines) to Poly(2-oxazoline-co-ethylene imines): Synthesis, Cytotoxicity and Complexing Efficiency with the Perspective for Biomedical Applications
Original language description
The versatility of 2-oxazolines and its (co)polymers such as poly (2-ethyl-2-oxazolines) (PETOx) and their ability to form biomaterials has been arising. A living cationic ring opening polymerization of 2-ethyl-2-oxazoline provides poly(2-ethyl-2-oxazolines), which are biocompatible and non-toxic polymers. Poly(ethylene imine), PEI, is well-known polymer used in different biomedical fields such as genetic engineering. However, its cytotoxicity is the main drawback for enhancing its potential in biomedical applications. Therefore, a partial acidic hydrolysis of PETOx leading to compolymer of PETOx with PEI is considered as a suitable way for the preparation of biosafe analogue to PEI. In our work, PETOx with varying molar mass wass prepared and used forthe synthesis of a series of poly(2-ethyl-2oxazoline-co-ethylene imine) copolymers by the controlled hydrolysis of PETOx within the time interval from 15 to 180 min. The structure and composition of the prepared copolymers were determine
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
CD - Macromolecular chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů