Partialy Hydrolyzed Poly (2-ethyl-2-oxazolines): Synthesis and Cytotoxicity Assay for Biomedical Applications

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F14%3A43872655" target="_blank" >RIV/70883521:28610/14:43872655 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Partialy Hydrolyzed Poly (2-ethyl-2-oxazolines): Synthesis and Cytotoxicity Assay for Biomedical Applications
Original language description
Polymers with the functional groups represent an important aspect in the medical field. 2-oxazolines and its co-polymer represents promising compound in the preparation of biomaterials as potential alternatives to Poly-ethylene glycol (PEG) which has disadvantage of having poor mechanical properties. These classes of synthetic polymers are very versatile and the living cationic polymerization of 2-ethyl-2-oxazolines giving rise to Poly (2-ethyl-2-oxazoline) (PETOx) which are biocompatible, thermo sensitive and non-toxic in nature. On the other hand poly (ethylene imine) (PEI), a highly branched cationic polymer is widely used in the drug delivery as transfecting agents and also in tissue engineering. But the cytotoxic issue is the main drawback in thePEI, so partially hydrolyzed PETOx with its copolymer as PETOx-PEI are prepared so that the cytotoxic level of PEI gets controlled. In this article we report about synthesis and characterization of partially hydrolyzed Poly (2-ethyl-2-oxa
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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