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DEVELOPMENT OF THERANOSTIC AGENTS BASED ON IRON OXIDE-GADOLINIUM-CHITOSAN FOR CONTROLLED RELEASE OF DOXORUBICIN

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F16%3A43875542" target="_blank" >RIV/70883521:28610/16:43875542 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    DEVELOPMENT OF THERANOSTIC AGENTS BASED ON IRON OXIDE-GADOLINIUM-CHITOSAN FOR CONTROLLED RELEASE OF DOXORUBICIN

  • Original language description

    Herein we report a theranostic system based on iron oxide-gadolinium nanoparticles coated by chitosan as a dual contrast agent for magnetic resonance imaging and controlled delivery application. Iron oxide nanoparticles were prepared by reduction of iron (III) chloride followed by surface modification using arenediazonium tosylate and diethylenetriaminepentaacetic acid for Gd(III) complexation. Nanoparticles were loaded with the anticancer drug doxorubicin and coated by low molecular weight chitosan to improve stability in solution and control the release of the drug. Dynamic light scattering,  -potential, thermogravimetric analysis, attenuated total refraction infrared spectroscopy and magnetic hysteresis curves reveal the success of surface modification and coating process. The amount of Gd(III) complexed and doxorubicin loaded were assessed by UV-Vis. Release studies were carried out in simulated physiological conditions. Results indicate that the obtained iron oxide-Gd(III)nanoparticles coated by chitosan are stable up to one month in physiological conditions and magnetic response is slightly decreased. The MRI analysis, doxorubicin high encapsulation efficiency and sustained release trend suggests that the presented system represents an interesting platform for the development of future theranostic agents.

  • Czech name

  • Czech description

Classification

  • Type

    D - Article in proceedings

  • CEP classification

  • OECD FORD branch

    10608 - Biochemistry and molecular biology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Article name in the collection

    Nanocon 2016

  • ISBN

    978-80-87294-68-0

  • ISSN

  • e-ISSN

    neuvedeno

  • Number of pages

    5

  • Pages from-to

    "neuveden"

  • Publisher name

    Tanger spol. s r. o.

  • Place of publication

    Ostrava

  • Event location

    Brno

  • Event date

    Oct 19, 2016

  • Type of event by nationality

    WRD - Celosvětová akce

  • UT code for WoS article