Novel PLA-Chitosan nanocomplexes for controlled and sustained release of DNA-Alkylating drugs
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F16%3A43875562" target="_blank" >RIV/70883521:28610/16:43875562 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Novel PLA-Chitosan nanocomplexes for controlled and sustained release of DNA-Alkylating drugs
Original language description
In the last decades the controlled and sustained release of drugs, in particular anticancer, from polymeric nanoparticles has attracted many researchers, with the aim to improve their therapeutic efficacy, targeting and reduce side effects. Among the various natural and synthetic polymers used for preparation of polymeric drug delivery systems, chitosan (CS) gained great interest due to its properties such as biocompatibility, biodegradability, non-toxicity and non-immunogenicity. CS in mild acid aqueous solution is positively charged allowing the formation of delivery systems based only on electrostatic interactions, which give the opportunity to modulate the release of loaded drug by changing the environment conditions.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů