Controlled release of enrofloxacin by vanillin-crosslinked chitosan-polyvinyl alcohol blends

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F21%3A63536699" target="_blank" >RIV/70883521:28610/21:63536699 - isvavai.cz</a>

Alternative codes found

RIV/70883521:28110/21:63536699

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0928493121002642" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0928493121002642</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.msec.2021.112125" target="_blank" >10.1016/j.msec.2021.112125</a>

Result language

angličtina

Original language name

Controlled release of enrofloxacin by vanillin-crosslinked chitosan-polyvinyl alcohol blends

Original language description

In transdermal drug delivery applications uniform drug distribution and sustained release are of great importance to decrease the side effects. In this direction in the present research, vanillin crosslinked chitosan (CS) and polyvinyl alcohol (PVA) blend based matrix-type transdermal system was prepared by casting and drying of aqueous solutions for local delivery of enrofloxacin (ENR) drug. Subsequently, the properties including the morphology, chemical structure, thermal behavior, tensile strength, crosslinking degree, weight uniformity, thickness, swelling and drug release of the CS-PVA blend films before and after crosslinking were characterized. In vitro drug release profiles showed the sustained release of ENR by the incorporation of vanillin as a crosslinker into the CS-PVA polymer matrix. Furthermore, the release kinetic profiles revealed that the followed mechanism for all samples was Higuchi and the increase of vanillin concentration in the blend films resulted in the change of diffusion mechanism from anomalous transport to Fickian diffusion. Overall, the obtained results suggest that the investigated vanillin crosslinked CS-PVA matrix-type films are potential candidates for transdermal drug delivery system.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10404 - Polymer science

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Materials Science and Engineering: C Materials for Biological Applications

ISSN

0928-4931

e-ISSN

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Volume of the periodical

126

Issue of the periodical within the volume

Neuveden

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

13

Pages from-to

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UT code for WoS article

000663454000001

EID of the result in the Scopus database

2-s2.0-85104802406